101311-04-0
Chemical Structure
Duartin
- CAS No.: 101311-04-0
- Formula:C18H20O6
- Molecular Weight:332.35
InChIKey: QVVPJFBYFYYVDM-NSHDSACASA-N
SMILES: COC1=C([C@H]2CC3=CC=C(O)C(OC)=C3OC2)C=CC(OC)=C1O
Biological Activity: Duartin is an isoflavan that exists in the heartwood of Dalbergia odorifera T. Chen, Machaerium opacum, and Machaerium villosum Vog. Duartin shows no obvious inhibitory effect on prostaglandin biosynthesis, fails to alleviate rat paw edema induced by carrageenan, dextran, or histamine, and cannot inhibit carrageenan-induced pleurisy in rats, reduce exudate volume, or suppress leukocyte migration[1][2][3].
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Duartin | Duartin is an isoflavan that exists in the heartwood of Dalbergia odorifera T. Chen, Machaerium opacum, and Machaerium villosum Vog. Duartin shows no obvious inhibitory effect on prostaglandin biosynthesis, fails to alleviate rat paw edema induced by carrageenan, dextran, or histamine, and cannot inhibit carrageenan-induced pleurisy in rats, reduce exudate volume, or suppress leukocyte migration. | |||||||||||||||||||||
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- [1]. Goda Y, et al. Inhibitors of prostaglandin biosynthesis from dalbergia odorifera. Chemical and Pharmaceutical Bulletin. 1985;33(12):5606-5609.
- [2]. Ollis WD, et al. Duartin, an isoflavan from Machaerium opacum. Phytochemistry. 1978;17(8):1401-1403.
- [3]. Emim JA, et al. Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. The Journal of pharmacy and pharmacology. 1994 Feb;46(2):118-22. [Content Brief]
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