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Cat. No.: HY-183447

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Duartin

Duartin is an isoflavan that exists in the heartwood of Dalbergia odorifera T. Chen, Machaerium opacum, and Machaerium villosum Vog. Duartin shows no obvious inhibitory effect on prostaglandin biosynthesis, fails to alleviate rat paw edema induced by carrageenan, dextran, or histamine, and cannot inhibit carrageenan-induced pleurisy in rats, reduce exudate volume, or suppress leukocyte migration.

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CAS No.: 101311-04-0
Formule: C₁₈H₂₀O₆
Masse moléculaire:332.35

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Please store the product under the recommended conditions in the Certificate of Analysis.

Duartin Chemical Structure

CAS No.: 101311-04-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

In Vitro

Duartin's structural isomer (±)-isoduartin exhibits prostaglandin synthetase inhibitory activity with an IC₅₀ value of 110 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Innate ImmunityOthers

Innate Immunity

Duartin (100 mg/kg; subcutaneous injection) does not reduce pleural exudate volume or leukocyte migration in a carrageenan-induced pleurisy model of Wistar rats^[3].

Others

Duartin (100 mg/kg, subcutaneous injection) does not reduce carrageenan-, dextran-, or histamine-induced paw edema in female Wistar rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 101311-04-0
Masse moléculaire 332.35
Formule C₁₈H₂₀O₆
SMILES

COC1=C([C@H]2CC3=CC=C(O)C(OC)=C3OC2)C=CC(OC)=C1O
Structure Classification
- Flavonoids
- Flavonones
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Goda Y, et al. Inhibitors of prostaglandin biosynthesis from dalbergia odorifera. Chemical and Pharmaceutical Bulletin. 1985;33(12):5606-5609.

[2]. Ollis WD, et al. Duartin, an isoflavan from Machaerium opacum. Phytochemistry. 1978;17(8):1401-1403.

[3]. Emim JA, et al. Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. The Journal of pharmacy and pharmacology. 1994 Feb;46(2):118-22. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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