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  3. Duartin

Duartin is an isoflavan that exists in the heartwood of Dalbergia odorifera T. Chen, Machaerium opacum, and Machaerium villosum Vog. Duartin shows no obvious inhibitory effect on prostaglandin biosynthesis, fails to alleviate rat paw edema induced by carrageenan, dextran, or histamine, and cannot inhibit carrageenan-induced pleurisy in rats, reduce exudate volume, or suppress leukocyte migration.

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Duartin

Duartin Chemical Structure

CAS No. : 101311-04-0

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Description

Duartin is an isoflavan that exists in the heartwood of Dalbergia odorifera T. Chen, Machaerium opacum, and Machaerium villosum Vog. Duartin shows no obvious inhibitory effect on prostaglandin biosynthesis, fails to alleviate rat paw edema induced by carrageenan, dextran, or histamine, and cannot inhibit carrageenan-induced pleurisy in rats, reduce exudate volume, or suppress leukocyte migration[1][2][3].

In Vitro

Duartin's structural isomer (±)-isoduartin exhibits prostaglandin synthetase inhibitory activity with an IC50 value of 110 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Duartin (100 mg/kg, subcutaneous injection) does not reduce carrageenan-, dextran-, or histamine-induced paw edema in female Wistar rats[3].
Duartin (100 mg/kg; subcutaneous injection) does not reduce pleural exudate volume or leukocyte migration in a carrageenan-induced pleurisy model of Wistar rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

332.35

Formula

C18H20O6

CAS No.
SMILES

COC1=C([C@H]2CC3=CC=C(O)C(OC)=C3OC2)C=CC(OC)=C1O

Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Duartin
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