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Cat. No.: HY-183447

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Duartin

Duartin is an isoflavan that exists in the heartwood of Dalbergia odorifera T. Chen, Machaerium opacum, and Machaerium villosum Vog. Duartin shows no obvious inhibitory effect on prostaglandin biosynthesis, fails to alleviate rat paw edema induced by carrageenan, dextran, or histamine, and cannot inhibit carrageenan-induced pleurisy in rats, reduce exudate volume, or suppress leukocyte migration.

For research use only. We do not sell to patients.

CAS No.: 101311-04-0
Formula: C₁₈H₂₀O₆
Molecular Weight:332.35

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Please store the product under the recommended conditions in the Certificate of Analysis.

Duartin Chemical Structure

CAS No.: 101311-04-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Duartin's structural isomer (±)-isoduartin exhibits prostaglandin synthetase inhibitory activity with an IC₅₀ value of 110 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Duartin (100 mg/kg, subcutaneous injection) does not reduce carrageenan-, dextran-, or histamine-induced paw edema in female Wistar rats^[3].
Duartin (100 mg/kg; subcutaneous injection) does not reduce pleural exudate volume or leukocyte migration in a carrageenan-induced pleurisy model of Wistar rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 101311-04-0
Molecular Weight 332.35
Formula C₁₈H₂₀O₆
SMILES

COC1=C([C@H]2CC3=CC=C(O)C(OC)=C3OC2)C=CC(OC)=C1O
Structure Classification
- Flavonoids
- Flavonones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Goda Y, et al. Inhibitors of prostaglandin biosynthesis from dalbergia odorifera. Chemical and Pharmaceutical Bulletin. 1985;33(12):5606-5609.

[2]. Ollis WD, et al. Duartin, an isoflavan from Machaerium opacum. Phytochemistry. 1978;17(8):1401-1403.

[3]. Emim JA, et al. Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. The Journal of pharmacy and pharmacology. 1994 Feb;46(2):118-22. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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