1020067-28-0
Chemical Structure
YM-359445 dihydroxybutanedioate
- CAS No.: 1020067-28-0
- Formula:C32H34N6O8S
- Molecular Weight:662.71
IUPAC Name: (E)-3-((Z)-6-((4-methylpiperazin-1-yl)methyl)quinolin-2(1H)-ylidene)-2-oxoindoline-6-carbaldehyde O-thiazol-4-ylmethyl oxime (2R,3R)-2,3-dihydroxysuccinate
InChIKey: JGNMGVDUZSRGNP-UPFYVKSISA-N
SMILES: OC([C@H](O)[C@@H](O)C(O)=O)=O.O=C1/C(C2=CC=C(/C=N/OCC3=CSC=N3)C=C2N1)=C4NC5=CC=C(CN6CCN(C)CC6)C=C5C=C\4
Biological Activity: YM-359445 dihydroxybutanedioate is an orally active VEGFR2 tyrosine kinase inhibitor, with an IC50 of 8.5 nM. YM-359445 dihydroxybutanedioate shows a complete inhibition of vascular permeability induced by VEGF. YM-359445 dihydroxybutanedioate shows antitumor activity against both lung cancer and Paclitaxel (HY-B0015)-resistant colon cancer[1].
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YM-359445 dihydroxybutanedioate | YM-359445 dihydroxybutanedioate is an orally active VEGFR2 tyrosine kinase inhibitor, with an IC50 of 8.5 nM. YM-359445 dihydroxybutanedioate shows a complete inhibition of vascular permeability induced by VEGF. YM-359445 dihydroxybutanedioate shows antitumor activity against both lung cancer and Paclitaxel (HY-B0015)-resistant colon cancer. | |||||||||||||||||||||
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Keywords
