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Cat. No.: HY-117039

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YM-359445 dihydroxybutanedioate

YM-359445 dihydroxybutanedioate is an orally active VEGFR2 tyrosine kinase inhibitor, with an IC₅₀ of 8.5 nM. YM-359445 dihydroxybutanedioate shows a complete inhibition of vascular permeability induced by VEGF. YM-359445 dihydroxybutanedioate shows antitumor activity against both lung cancer and Paclitaxel (HY-B0015)-resistant colon cancer.

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CAS No.: 1020067-28-0
Formule: C₃₂H₃₄N₆O₈S
Masse moléculaire:662.71

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

YM-359445 dihydroxybutanedioate Chemical Structure

CAS No.: 1020067-28-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

VEGFR2

8.5 nM (IC₅₀)

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Chemical Information

CAS No. 1020067-28-0
Masse moléculaire 662.71
Formule C₃₂H₃₄N₆O₈S
SMILES

OC([C@H](O)[C@@H](O)C(O)=O)=O.O=C1/C(C2=CC=C(/C=N/OCC3=CSC=N3)C=C2N1)=C4NC5=CC=C(CN6CCN(C)CC6)C=C5C=C\4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Amino N, et al. YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors. Clin Cancer Res. 2006 Mar 1;12(5):1630-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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YM-359445 dihydroxybutanedioate

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Activité biologique
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- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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YM-359445 dihydroxybutanedioate

Voir tous les produits spécifiques à Isoform VEGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

YM-359445 dihydroxybutanedioate Related Classifications

HY-117039 Related Classifications