102047-34-7
Chemical Structure
ATP ditromethamine
Synonym(s): Adenosine 5'-triphosphate ditromethamine
- CAS No.: 102047-34-7
- Formula:C18H38N7O19P3
- Molecular Weight:749.45
IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol hemi(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl triphosphate)
InChIKey: RFLPQCVEEHGPOA-IDIVVRGQSA-N
SMILES: O=P(O)(O)OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1O)(O)=O)(O)=O.OCC(CO)(N)CO.OCC(CO)(N)CO
Biological Activity: ATP (Adenosine 5'-triphosphate) ditromethamine is a central component of energy storage and metabolism in vivo. ATP ditromethamine provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP ditromethamine is an important endogenous signaling molecule in immunity and inflammation. ATP ditromethamine can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP ditromethamine has anti-bacterial infection effects and can protect mice against bacterial infection in mice[1][2][3][4].
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ATP ditromethamine | ATP (Adenosine 5'-triphosphate) ditromethamine is a central component of energy storage and metabolism in vivo. ATP ditromethamine provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP ditromethamine is an important endogenous signaling molecule in immunity and inflammation. ATP ditromethamine can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP ditromethamine has anti-bacterial infection effects and can protect mice against bacterial infection in mice. | |||||||||||||||||||||
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References
- [1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [Content Brief]
- [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [Content Brief]
- [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [Content Brief]
- [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. [Content Brief]
