104795-68-8
Chemical Structure
CI-959
- CAS No.: 104795-68-8
- Formula:C14H15N5NaO3S
- Molecular Weight:356.36
IUPAC Name: 3-isopropoxy-5-methoxy-N-(1H-tetrazol-5-yl)benzo[b]thiophene-2-carboxamide, sodium salt
InChIKey: WEPDZDGEBWNUPX-UHFFFAOYSA-N
SMILES: COC1=CC=C2C(C(OC(C)C)=C(C(NC3=NN=NN3)=O)S2)=C1.[Na]
Biological Activity: CI-959 is an inhibitor of inflammatory cell activation. CI-959 exhibits anti-inflammatory and anti-allergic activities. CI-959 can inhibit the production of reactive oxygen species by neutrophils, as well as neutrophil adhesion, respiratory burst, and histamine release from mast cells. CI-959 can also inhibit the release of inflammatory mediators such as histamine, leukotrienes, and thromboxane from guinea-pig and human lung tissues, and effectively suppress anti-IgE-induced contractions of human bronchial smooth muscle. CI-959 can be used in the research of inflammatory and allergic diseases, such as asthma[1][2][3].
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CI-959 | CI-959 is an inhibitor of inflammatory cell activation. CI-959 exhibits anti-inflammatory and anti-allergic activities. CI-959 can inhibit the production of reactive oxygen species by neutrophils, as well as neutrophil adhesion, respiratory burst, and histamine release from mast cells. CI-959 can also inhibit the release of inflammatory mediators such as histamine, leukotrienes, and thromboxane from guinea-pig and human lung tissues, and effectively suppress anti-IgE-induced contractions of human bronchial smooth muscle. CI-959 can be used in the research of inflammatory and allergic diseases, such as asthma. | |||||||||||||||||||||
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- [1]. Adolphson RL, et al. CI-959, a new, potential antiallergic drug, inhibits mediator release from lung and contractions of human airways in vitro. Int Arch Allergy Appl Immunol. 1990;93(2-3):267-71. [Content Brief]
- [2]. Burke SE, et al. Reduction of canine myocardial infarct size by CI-959, an inhibitor of inflammatory cell activation. J Cardiovasc Pharmacol. 1992 Oct;20(4):619-29. [Content Brief]
- [3]. Low J, et al. Cytoprotective effects of CI-959 in the rat gastric mucosa: modulation of leukocyte adhesion. Gastroenterology. 1995 Oct;109(4):1224-33. [Content Brief]
Keywords
