104958-90-9
104958-90-9
Chemical Structure
Sanazole
Synonym(s): AK-2123
- CAS No.: 104958-90-9
- Formula:C7H11N5O4
- Molecular Weight:229.19
IUPAC Name: N-(2-methoxyethyl)-2-(3-nitro-1H-1,2,4-triazol-1-yl)acetamide
InChIKey: YKDRHKCETNMLHL-UHFFFAOYSA-N
SMILES: O=C(NCCOC)CN1N=C([N+]([O-])=O)N=C1
Biological Activity: Sanazole (AK-2123) is a hypoxic cell radiosensitizer. Sanazole enhances radiation-induced DNA strand breaks. In mouse fibroblast tumors, Sanazole increases nuclear condensation and fragmentation, as well as elevates caspase-3 activity, thereby enhancing radiation-induced apoptosis[1][2].
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Sanazole | Sanazole (AK-2123) is a hypoxic cell radiosensitizer. Sanazole enhances radiation-induced DNA strand breaks. In mouse fibroblast tumors, Sanazole increases nuclear condensation and fragmentation, as well as elevates caspase-3 activity, thereby enhancing radiation-induced apoptosis. | |||||||||||||||||||||
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References
- [1]. Rajagopalan, et al. Radiosensitizer Sanazole (AK-2123) enhances γ-radiation-induced Apoptosis in murine fibrosarcoma. Journal of radiation research 44.4 (2003): 359-365. [Content Brief]
- [2]. García-Angulo, et al. "Intratumoral and parametrial infusion of a 3-nitrotriazole (AK-2123) in the radiotherapy of the uterine cervix cancer: stage II–III—preliminary positive results." International Journal of Radiation Oncology Biology Physics 22.3 (1992): 589-591. [Content Brief]
Keywords
