1100361-36-1
Chemical Structure
SCH 900229
- CAS No.: 1100361-36-1
- Formula:C21H21ClF2O6S2
- Molecular Weight:506.97
IUPAC Name: (4S,4aS,10bS)-10b-((4-chlorophenyl)sulfonyl)-7,10-difluoro-4-(2-(methylsulfonyl)ethyl)-1,4a,5,10b-tetrahydro-2H,4H-pyrano[3,4-c]chromene
InChIKey: AMXSRXZYBDALJG-XERREHJYSA-N
SMILES: O=S([C@]12C3=C(F)C=CC(F)=C3OC[C@@]1([H])[C@@H](OCC2)CCS(C)(=O)=O)(C4=CC=C(C=C4)Cl)=O
Biological Activity: SCH 900229 is a potent γ-secretase inhibitor with selective activity against PS1. The Aβ40 IC50 value of SCH 900229 is 1.3 nM, showing its excellent ability in reducing Aβ. SCH 900229 has shown good Aβ-lowering effects after oral administration in preclinical animal models. SCH 900229 has been advanced to human clinical trials for further development of compounds for the inhibition of Alzheimer's disease[1].
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SCH 900229 | SCH 900229 is a potent γ-secretase inhibitor with selective activity against PS1. The Aβ40 IC50 value of SCH 900229 is 1.3 nM, showing its excellent ability in reducing Aβ. SCH 900229 has shown good Aβ-lowering effects after oral administration in preclinical animal models. SCH 900229 has been advanced to human clinical trials for further development of compounds for the inhibition of Alzheimer's disease. | |||||||||||||||||||||
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Keywords
