1119536-89-8
Chemical Structure
CK-571
- CAS No.: 1119536-89-8
- Formula:C24H26ClFN4O5
- Molecular Weight:504.94
InChIKey: HLEXQOJKMXKUKE-RBUKOAKNSA-N
SMILES: O=C(OC[C@H](C[C@@H](O)CO)N(C)C(NCC1=C(Cl)C(F)=CC=C1)=O)NC2=NC=C3C(C=CC=C3)=C2
Biological Activity: CK-571 is a potent and selective inhibitor of smooth muscle myosin-2 (SMM), with an IC50 value of 86 nM. CK-571 exhibits IC50 values for cardiac muscle myosin (CMM), skeletal muscle myosin (SKM), and non-muscle myosin-2A (NMM-2A) of 2.3, 42, and 0.58 μM, respectively. CK-571 can be used for research on asthma, chronic obstructive pulmonary disease, and other smooth muscle-related diseases[1].
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CK-571 | CK-571 is a potent and selective inhibitor of smooth muscle myosin-2 (SMM), with an IC50 value of 86 nM. CK-571 exhibits IC50 values for cardiac muscle myosin (CMM), skeletal muscle myosin (SKM), and non-muscle myosin-2A (NMM-2A) of 2.3, 42, and 0.58 μM, respectively. CK-571 can be used for research on asthma, chronic obstructive pulmonary disease, and other smooth muscle-related diseases. | |||||||||||||||||||||
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Keywords
