2. Cytoskeleton
  3. Myosin
  4. CK-571

CK-571 is a potent and selective inhibitor of smooth muscle myosin-2 (SMM), with an IC50 value of 86 nM. CK-571 exhibits IC50 values for cardiac muscle myosin (CMM), skeletal muscle myosin (SKM), and non-muscle myosin-2A (NMM-2A) of 2.3, 42, and 0.58 μM, respectively. CK-571 can be used for research on asthma, chronic obstructive pulmonary disease, and other smooth muscle-related diseases.

For research use only. We do not sell to patients.

CK-571

CK-571 Chemical Structure

CAS No. : 1119536-89-8

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Description

CK-571 is a potent and selective inhibitor of smooth muscle myosin-2 (SMM), with an IC50 value of 86 nM. CK-571 exhibits IC50 values for cardiac muscle myosin (CMM), skeletal muscle myosin (SKM), and non-muscle myosin-2A (NMM-2A) of 2.3, 42, and 0.58 μM, respectively. CK-571 can be used for research on asthma, chronic obstructive pulmonary disease, and other smooth muscle-related diseases[1].

Molecular Weight

504.94

Formula

C24H26ClFN4O5
CAS No.
SMILES

O=C(OC[C@H](C[C@@H](O)CO)N(C)C(NCC1=C(Cl)C(F)=CC=C1)=O)NC2=NC=C3C(C=CC=C3)=C2
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CK-571 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CK-5711119536-89-8CK571CK 571MyosinFragment-based SAR analysisMyosin-2Smooth muscle relaxationAsthma and COPDInhibitorinhibitorinhibit

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