1121931-70-1
Chemical Structure
CM398
- CAS No.: 1121931-70-1
- Formula:C23H29N3O3
- Molecular Weight:395.49
IUPAC Name: (1R,5S)-3-(benzhydryloxy)-8-(methyl-13C-d3)-8-azabicyclo[3.2.1]octane methanesulfonate
InChIKey: FKMMUKDTVNOKQD-UHFFFAOYSA-N
SMILES: O=C1N(C)C2=C(N1CCCCN3CC4=CC(OC)=C(C=C4CC3)OC)C=CC=C2
Biological Activity: CM398 is a highly selective, orally active Sigma-2 receptor ligand with a Ki value of 0.43 nM. CM398 ameliorates age-related macular degeneration. CM398 exerts analgesic effects on visceral pain, inflammatory pain and neuropathic pain. CM398 can be used in research related to age-related macular degeneration, neuropathic pain and inflammatory pain[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CM398 | 99.85% | CM398 is a highly selective, orally active Sigma-2 receptor ligand with a Ki value of 0.43 nM. CM398 ameliorates age-related macular degeneration. CM398 exerts analgesic effects on visceral pain, inflammatory pain and neuropathic pain. CM398 can be used in research related to age-related macular degeneration, neuropathic pain and inflammatory pain. | ||||||||||||||||||||
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References
- [1]. Mavlyutov TA, et al. Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation. Genes (Basel). 2022;13(12):2386. Published 2022 Dec 16. [Content Brief]
- [2]. Wilson LL, et al. Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain. Molecules. 2022;27(11):3617. Published 2022 Jun 4. [Content Brief]
- [3]. Intagliata S, et al. Discovery of a highly selective sigma-2 receptor ligand, 1-(4-(6, 7-Dimethoxy-3, 4-dihydroisoquinolin-2 (1 H)-yl) butyl)-3-methyl-1 H-benzo [d] imidazol-2 (3 H)-one (CM398), with drug-like properties and antinociceptive effects in vivo[J]. The AAPS Journal, 2020, 22(5): 94.
