112827-99-3
Chemical Structure
24R-Calcipotriol
Synonym(s): PRI 2202; Impurity D of Calcipotriol
- CAS No.: 112827-99-3
- Formula:C27H40O3
- Molecular Weight:412.60
IUPAC Name: (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((2R,5R,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
InChIKey: LWQQLNNNIPYSNX-CIJZWTHJSA-N
SMILES: O[C@H]1C[C@H](O)C(/C(C1)=C\C=C2[C@]3([H])CC[C@H]([C@H](C)/C=C/[C@@H](C4CC4)O)[C@@]3(C)CCC\2)=C
Biological Activity: 24R-Calcipotriol (PRI 2202; Impurity D of Calcipotriol), an isomer of Calcipotriol (HY-10001), is a synthetic vitamin D analog. 24R-Calcipotriol exhibits synergistic antiproliferative effects with low-dose cytostatics in in vitro. 24R-Calcipotriol produces tumor growth inhibition when combined with Cyclophosphamide (HY-17420) and Cisplatin (HY-17394) in mice models. 24R-Calcipotriol can increase serum calcium levels and reduce blood leukocyte counts. 24R-Calcipotriol can be used for the research of mammary cancer and Lewis lung cancer[1][2].
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24R-Calcipotriol | 94.85% | 24R-Calcipotriol (PRI 2202; Impurity D of Calcipotriol), an isomer of Calcipotriol (HY-10001), is a synthetic vitamin D analog. 24R-Calcipotriol exhibits synergistic antiproliferative effects with low-dose cytostatics in in vitro. 24R-Calcipotriol produces tumor growth inhibition when combined with Cyclophosphamide (HY-17420) and Cisplatin (HY-17394) in mice models. 24R-Calcipotriol can increase serum calcium levels and reduce blood leukocyte counts. 24R-Calcipotriol can be used for the research of mammary cancer and Lewis lung cancer. | ||||||||||||||||||||
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24R-Calcipotriol-d4 | 24R-Calcipotriol-d4 (PRI 2202-d4; Impurity D of Calcipotriol-d4) is the deuterium labeled 24R-Calcipotriol. 24R-Calcipotriol is an impurity of Calcipotriol. Calcipotriol is a ligand of VDR-like receptors. | |||||||||||||||||||||
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- [1]. Wietrzyk J, et al. The antitumor effect of lowered doses of cytostatics combined with new analogs of vitamin D in mice. Anticancer Res. 2007;27(5A):3387-3398. [Content Brief]
- [2]. Norton R, et al. Vitamin D: potential in the prevention and treatment of lung cancer[J]. Anticancer research, 2012, 32(1): 211-221.
Keywords
