115621-24-4
Chemical Structure
Pyrrolidone carboxylic acid
Synonym(s): PCA
- CAS No.: 115621-24-4
- Formula:C5H7NO3
- Molecular Weight:129.11
IUPAC Name: 2-oxopyrrolidine-1-carboxylic acid
InChIKey: DQAKJEWZWDQURW-UHFFFAOYSA-N
SMILES: O=C(N1C(CCC1)=O)O
Biological Activity: Pyrrolidone carboxylic acid (PCA) is one of the main components (accounting for approximately 12%) of natural moisturizing factors (NMF) in the mammalian epidermal stratum corneum, and it is produced by the degradation of filaggrin. It exhibits multiple biological activities such as skin moisturization, central GABA release, anxiolysis, and auxiliary ethanol metabolism. The content of Pyrrolidone carboxylic acid correlates with the clinical severity of atopic dermatitis lesions, skin barrier function, and inflammation levels, and shows a negative correlation with the expression of TNF-α and IL-13. Pyrrolidone carboxylic acid can serve as a key skin biomarker for skin barrier function and health[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Pyrrolidone carboxylic acid | Pyrrolidone carboxylic acid (PCA) is one of the main components (accounting for approximately 12%) of natural moisturizing factors (NMF) in the mammalian epidermal stratum corneum, and it is produced by the degradation of filaggrin. It exhibits multiple biological activities such as skin moisturization, central GABA release, anxiolysis, and auxiliary ethanol metabolism. The content of Pyrrolidone carboxylic acid correlates with the clinical severity of atopic dermatitis lesions, skin barrier function, and inflammation levels, and shows a negative correlation with the expression of TNF-α and IL-13. Pyrrolidone carboxylic acid can serve as a key skin biomarker for skin barrier function and health. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Pellegrini-Giampietro DE, Moroni F, Pistelli A, et al.. Pyrrolidone carboxylic acid in acute and chronic alcoholism. Preclinical and clinical studies. Recenti progressi in medicina. 1989 Mar;80(3):160-4. [Content Brief]
- [2]. Jung M, Choi J, Lee SA, et al.. Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis. Journal of dermatological science. 2014 Dec;76(3):231-9. [Content Brief]
- [3]. Barrett JG, Scott IR. Pyrrolidone carboxylic acid synthesis in guinea pig epidermis. The Journal of investigative dermatology. 1983 Aug;81(2):122-4. [Content Brief]
Keywords
