1189992-00-4
1189992-00-4
Chemical Structure
Roflumilast-d3
Synonym(s): APTA-2217-d3;BYK 20869-d3;B9302-107-d3
- CAS No.: 1189992-00-4
- Formula:C17H11D3Cl2F2N2O3
- Molecular Weight:406.23
IUPAC Name: 3-((cyclopropyl-1-d)methoxy-d2)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
InChIKey: MNDBXUUTURYVHR-YBGYDHGYSA-N
SMILES: [2H]C1(CC1)C([2H])([2H])OC2=C(C=CC(C(NC3=C(Cl)C=NC=C3Cl)=O)=C2)OC(F)F
Biological Activity: Roflumilast-d3 is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Roflumilast-d3 | Roflumilast-d3 is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells. | |||||||||||||||||||||
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Roflumilast (Standard) | ≥98% | Roflumilast (Standard) is the analytical standard of Roflumilast. This product is intended for research and analytical applications. Roflumilast (APTA-2217) is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells. | ||||||||||||||||||||
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Roflumilast-d4 | 97.26% | Roflumilast-d4 is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells. | ||||||||||||||||||||
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Roflumilast | 99.98% | Roflumilast (APTA-2217) is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDE4A4, PDE4B1, and PDE4B2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells. | ||||||||||||||||||||
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