1190598-60-7
Chemical Structure
CFMMC
- CAS No.: 1190598-60-7
- Formula:C22H28FNO4
- Molecular Weight:389.46
IUPAC Name: 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholinoethoxy)-4H-chromen-4-one
InChIKey: PHQKNLJAPYWXQQ-UHFFFAOYSA-N
SMILES: O=C1C2=C(OC=C1C3CCCCC3)C=C(OCCN4CCOCC4)C(C)=C2F
Biological Activity: CFMMC is a selective allosteric metabotropic glutamate receptor 1 (mGluR1) antagonist. CFMMC inhibits L-glutamate-induced intracellular Ca2+ mobilization ([Ca2+]i) in Chinese hamster ovary cells expressing recombinant human mGluR1a with an IC50 value of 50 nM. CFMMC is promising for research of various central nervous system disorders, such as schizophrenia, epilepsy, anxiety, pain, cognitive dysfunction and drug abuse[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CFMMC | CFMMC is a selective allosteric metabotropic glutamate receptor 1 (mGluR1) antagonist. CFMMC inhibits L-glutamate-induced intracellular Ca2+ mobilization ([Ca2+]i) in Chinese hamster ovary cells expressing recombinant human mGluR1a with an IC50 value of 50 nM. CFMMC is promising for research of various central nervous system disorders, such as schizophrenia, epilepsy, anxiety, pain, cognitive dysfunction and drug abuse. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Fukuda J, et al. Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one. Neuropharmacology. 2009 Sep;57(4):438-45. [Content Brief]
Keywords
