120243-02-9
Chemical Structure
Myxochelin A
Synonym(s): (S)-Myxochelin A
- CAS No.: 120243-02-9
- Formula:C20H24N2O7
- Molecular Weight:404.41
IUPAC Name: (S)-N,N'-(6-hydroxyhexane-1,5-diyl)bis(2,3-dihydroxybenzamide)
InChIKey: WNBVGSNESTZACV-LBPRGKRZSA-N
SMILES: OC[C@@H](NC(C1=CC=CC(O)=C1O)=O)CCCCNC(C2=CC=CC(O)=C2O)=O
Biological Activity: Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities. It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50 value of 1.9 μM for the recombinant human enzyme. It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/mL.
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Myxochelin A | Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities. It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50 value of 1.9 μM for the recombinant human enzyme. It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/mL. | |||||||||||||||||||||
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Keywords
