1217696-12-2
Chemical Structure
Fmoc-His(Trt)-OH-15N3
- CAS No.: 1217696-12-2
- Formula:C40H3315N3O4
- Molecular Weight:622.69
IUPAC Name: Na-(((9H-fluoren-9-yl)methoxy)carbonyl)-Nt-trityl-L-histidine-15N3
InChIKey: XXMYDXUIZKNHDT-SQMNLGFBSA-N
SMILES: O=C(O)[C@H](CC1=C[15N](C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=[15N]1)[15NH]C(OCC5C6=C(C7=C5C=CC=C7)C=CC=C6)=O
Biological Activity: Fmoc-His(Trt)-OH-15N3 is the 15N labeled Fmoc-His(Trt)-OH (HY-W010712). Fmoc-His (Trt)-OH is a histidine derivative. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation[1][2][3].
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Fmoc-His(Trt)-OH-15N3 | Fmoc-His(Trt)-OH-15N3 is the 15N labeled Fmoc-His(Trt)-OH (HY-W010712). Fmoc-His (Trt)-OH is a histidine derivative. Fmoc-His(Trt)-OH has trityl (Trt) group to protect the side-chain of His. Fmoc-His(Trt)-OH has Fmoc group to protect -αNH2. Fmoc-His(Trt)-OH can be used for solid phase synthesis of peptides, providing protection against racemization and by-product formation. | |||||||||||||||||||||
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Fmoc-His(Trt)-OH | 99.88% | Fmoc-His(Trt)-OH is a histidine derivative with a trityl (Trt) group protecting the His side chain. Fmoc-His(Trt)-OH also has an Fmoc group protecting the α-NH2 group. Fmoc-His(Trt)-OH can be used in solid-phase peptide synthesis to prevent racemization and byproduct formation. Fmoc-His(Trt)-OH acts as a protected histidine precursor in solid-phase peptide synthesis (SPPS), participating in peptide chain construction through amide bond formation. Fmoc-His(Trt)-OH can be precisely incorporated into the target peptide sequence, ensuring correct peptide chain synthesis and reducing impurity formation. Fmoc-His(Trt)-OH is mainly used in the solid-phase synthesis research of pharmaceutical peptides and bioactive peptides, and is particularly suitable for the preparation of peptide drugs requiring precise control of histidine configuration. | ||||||||||||||||||||
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- [1]. Yi Y, et, al. Suppression of Simultaneous Fmoc-His(Trt)-OH Racemization and Nα-DIC-Endcapping in Solid-Phase Peptide Synthesis through Design of Experiments and Its Implication for an Amino Acid Activation Strategy in Peptide Synthesis. Org. Process Res. Dev. 2022 Jun 27.
- [2]. Aggarwal S, et al. [DLys(6)]-luteinizing hormone releasing hormone-curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo. Int J Cancer. 2011 Oct 1;129(7):1611-23. [Content Brief]
- [3]. Kamysz E, et al. Characterization of the effects of opiorphin and sialorphin and their analogs substituted in position 1 with pyroglutamic acid on motility in the mouse ileum. J Pept Sci. 2013 Mar;19(3):166-72. [Content Brief]
