1232841-78-9
Chemical Structure
PBT434
Synonym(s): ATH434
- CAS No.: 1232841-78-9
- Formula:C12H14BrCl2N3O2
- Molecular Weight:383.07
IUPAC Name: 5,7-dichloro-2-((ethylamino)methyl)-8-hydroxy-3-methylquinazolin-4(3H)-one hydrobromide
InChIKey: WNTSHYWJAPIRQE-UHFFFAOYSA-N
SMILES: O=C1N(C)C(CNCC)=NC2=C1C(Cl)=CC(Cl)=C2O.Br
Biological Activity: PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 has the potential for the research of Parkinson’s disease (PD)[1].
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PBT434 | 98.86% | PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 has the potential for the research of Parkinson’s disease (PD). | ||||||||||||||||||||
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