1233921-74-8
1233921-74-8
Chemical Structure
Gemcitabine-13C,15N2
Synonym(s): LY 188011-13C,15N2
- CAS No.: 1233921-74-8
- Formula:C813CH11F2N15N2O4
- Molecular Weight:266.18
InChIKey: SDUQYLNIPVEERB-IETQKPOASA-N
SMILES: NC(C=C[15N]1[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2)=[15N][13C]1=O
Biological Activity: antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gemcitabine-13C,15N2 | 99.23% | antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. | ||||||||||||||||||||
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Gemcitabine (Standard) | 99.99% | Gemcitabine (Standard) is the analytical standard of Gemcitabine. This product is intended for research and analytical applications. Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis. | ||||||||||||||||||||
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Gemcitabine | 99.95% | Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, and can modulate autophagy. Gemcitabine induces apoptosis through the activation of p38 MAPK. Gemcitabine demonstrates efficacy in mouse models of pancreatic and breast cancer. Gemcitabine can be used for cancer research, such as pancreatic cancer, non-small cell lung cancer, and breast cancer. | ||||||||||||||||||||
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References
- [1]. Wang H, et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80. [Content Brief]
- [2]. Gagnadoux F, et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer;18(2):198-206. [Content Brief]
