1236667-40-5
1236667-40-5
Chemical Structure
Ifidancitinib
Synonym(s): ATI-50002; ATI-502
- CAS No.: 1236667-40-5
- Formula:C20H18FN5O3
- Molecular Weight:395.39
IUPAC Name: 5-((2-((4-fluoro-3-methoxy-5-methylphenyl)amino)-5-methylpyrimidin-4-yl)amino)benzo[d]oxazol-2(3H)-one
InChIKey: OYFMQDVLFYKOPZ-UHFFFAOYSA-N
SMILES: O=C1OC2=CC=C(NC3=NC(NC4=CC(C)=C(F)C(OC)=C4)=NC=C3C)C=C2N1
Biological Activity: Ifidancitinib (ATI-50002) is an orally available, potent and selective inhibitor of JAK kinase 1/3 that disrupts γc cytokine signaling. Ifidancitinib is used in the research of allergy, asthma, and autoimmune diseases[1][2].
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Ifidancitinib | 98.01% | Ifidancitinib (ATI-50002) is an orally available, potent and selective inhibitor of JAK kinase 1/3 that disrupts γc cytokine signaling. Ifidancitinib is used in the research of allergy, asthma, and autoimmune diseases. | ||||||||||||||||||||
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Ifidancitinib (Standard) | ≥98% | Ifidancitinib (Standard) is the analytical standard of Ifidancitinib (HY-109178). This product is intended for research and analytical applications. Ifidancitinib (ATI-50002) is an orally available, potent and selective inhibitor of JAK Kinase 1/3 that disrupts γc cytoKine signaling. Ifidancitinib is used in the research of allergy, asthma, and autoimmune diseases. | ||||||||||||||||||||
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References
- [1]. Li, Hui; Heckrodt, Thilo J.; Chen, Yan; Mcmurtrie, Darren John; Taylor, Vanessa; Singh, Rajinder; Ding, Pingyu; Yen, Rose.Preparation of phenylaminopyrimidinylaminooxobenzooxazole derivatives for use as JAK kinase inhibitors. WO2012015972A1
- [2]. Zhenpeng Dai, et al. Induction of T cell exhaustion by JAK1/3 inhibition in the treatment of alopecia areata. Front Immunol. 2022 Sep 20:13:955038. [Content Brief]
