124020-62-8
Chemical Structure
U-85548E
- CAS No.: 124020-62-8
- Formula:C40H73N9O12
- Molecular Weight:872.06
InChIKey: BURQLNQHSQGPEJ-ZSNIWDNKSA-N
SMILES: CC(C)[C@H](N)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O
Biological Activity: U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-activity relationship, a potent nanomolar inhibitor with inhibitory effects on both HIV-1 and HIV-2 proteases was designed, and its binding mode was studied by X-ray crystallography and molecular modeling.
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U-85548E | U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-activity relationship, a potent nanomolar inhibitor with inhibitory effects on both HIV-1 and HIV-2 proteases was designed, and its binding mode was studied by X-ray crystallography and molecular modeling. | |||||||||||||||||||||
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Keywords
