125113-96-4
125113-96-4
Chemical Structure
DCDAPH
- CAS No.: 125113-96-4
- Formula:C16H15N3
- Molecular Weight:249.31
IUPAC Name: 1-(tert-butylsulfonyl)-5,5-dimethylpyrrolidin-3-one
InChIKey: BFARWNGBCHXSTB-GGWOSOGESA-N
SMILES: CN(C1=CC=C(/C=C/C=C/C=C(C#N)/C#N)C=C1)C
Biological Activity: DCDAPH (Compound 2c) is a novel smart NIRF probe for detection of β-amyloid (Aβ) plaques (λex/λem=597/665 nm in PBS). DCDAPH shows high affinity for Aβ aggregates (Ki=37 nM, Kd=27 nM). DCDAPH shows good blood brain barrier permeation and can meet most of the requirements for the detection of Aβ plaques both in vitro and in vivo[1].
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DCDAPH | DCDAPH (Compound 2c) is a novel smart NIRF probe for detection of β-amyloid (Aβ) plaques (λex/λem=597/665 nm in PBS). DCDAPH shows high affinity for Aβ aggregates (Ki=37 nM, Kd=27 nM). DCDAPH shows good blood brain barrier permeation and can meet most of the requirements for the detection of Aβ plaques both in vitro and in vivo. | |||||||||||||||||||||
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References
Keywords
