125141-02-8
Chemical Structure
Spectramide
- CAS No.: 125141-02-8
- Formula:C19H23ClIN3O2
- Molecular Weight:487.76
InChIKey: SSXZAENYAVXXOA-UHFFFAOYSA-N
SMILES: O=C(C1=CC(Cl)=C(NC)C=C1OC)NCCN(CC2=CC=C(C=C2)I)C
Biological Activity: Spectramide is a blood-brain barrier-permeable, reversible, and selective dopamine D2 receptor ligand. Spectramide shows no strong interactions with dopamine D1 receptors, dopamine uptake sites, adrenergic receptor systems, cholinergic receptor systems, or 5-HTR systems. Spectramide can be labeled with 11C or 123I isotopes for use in PET or SPECT. Spectramide preferentially accumulates in the striatum with low uptake in other brain regions, and its accumulation can be blocked by pre-administration of Haloperidol (HY-14538)[1].
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Spectramide | Spectramide is a blood-brain barrier-permeable, reversible, and selective dopamine D2 receptor ligand. Spectramide shows no strong interactions with dopamine D1 receptors, dopamine uptake sites, adrenergic receptor systems, cholinergic receptor systems, or 5-HTR systems. Spectramide can be labeled with 11C or 123I isotopes for use in PET or SPECT. Spectramide preferentially accumulates in the striatum with low uptake in other brain regions, and its accumulation can be blocked by pre-administration of Haloperidol (HY-14538). | |||||||||||||||||||||
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Keywords
