1261398-47-3
Chemical Structure
5-Aminosalicylic acid-13C6 hydrochloride
Synonym(s): Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride
- CAS No.: 1261398-47-3
- Formula:C13C6H8ClNO3
- Molecular Weight:195.55
IUPAC Name: 5-amino-2-hydroxybenzoic-1,2,3,4,5,6-13C6 acid hydrochloride
InChIKey: KKRSNTURHSOKTM-BVNCJLROSA-N
SMILES: OC([13C]1=[13C]([13CH]=[13CH][13C](N)=[13CH]1)O)=O.Cl
Biological Activity: 5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3].
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5-Aminosalicylic acid-13C6 hydrochloride | 99.53% | 5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. | ||||||||||||||||||||
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- [1]. Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015;1853(10 Pt A):2349-2360. [Content Brief]
- [2]. Fang HM, et al. 5-aminosalicylic acid in combination with nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007;13(20):2872-2877. [Content Brief]
- [3]. Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013;34(11):2580-2586. [Content Brief]
