1310680-64-8
1310680-64-8
Chemical Structure
Ozanezumab
Synonym(s): GSK1223249
- CAS No.: 1310680-64-8
- Formula:N/A
- Molecular Weight:(145.227 kDa)
SMILES: [Ozanezumab]
Biological Activity: Ozanezumab (GSK1223249) is a humanized, Fc-inactivated monoclonal antibody that targets the nervous system protein Nogo-A. Ozanezumab promotes neurite outgrowth and axonal regeneration by neutralizing Nogo-A signaling. Ozanezumab is used for research on neurodegenerative diseases such as amyotrophic lateral sclerosis and multiple sclerosis[1][2][3].
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Ozanezumab | 99% | Ozanezumab (GSK1223249) is a humanized, Fc-inactivated monoclonal antibody that targets the nervous system protein Nogo-A. Ozanezumab promotes neurite outgrowth and axonal regeneration by neutralizing Nogo-A signaling. Ozanezumab is used for research on neurodegenerative diseases such as amyotrophic lateral sclerosis and multiple sclerosis. | ||||||||||||||||||||
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References
- [2]. Meininger V, et al. Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Neurol. 2017;16(3):208-216. [Content Brief]
- [3]. Anthony M. Lynch, et al. Non-clinical development of ozanezumab: a humanised antibody targeting the amino terminus of neurite outgrowth inhibitor A (Nogo-A), Toxicology Research, Volume 4, Issue 5, September 2015, Pages 1333–1343.
Keywords
