1312473-63-4
1312473-63-4
Chemical Structure
PF-5081090
Synonym(s): LpxC-4
- CAS. Nr.: 1312473-63-4
- Formula:C18H21FN2O6S
- Molecular Weight:412.43
IUPAC Name: (R)-4-(4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide
InChIKey: DNVUWHWBCMGQLU-GOSISDBHSA-N
SMILES: FC1=C(C2=CC(N(CC[C@](S(C)(=O)=O)(C)C(NO)=O)C=C2)=O)C=CC(OC)=C1
Biological Activity: PF-5081090 (LpxC-4) is a potent LpxC inhibitor, is a rapidly bactericidal with broad-spectrum activity. PF-5081090 serves as a regulator of lipid A biosynthesis in Gram-negative pathogens[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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PF-5081090 | 99.42% | PF-5081090 (LpxC-4) is a potent LpxC inhibitor, is a rapidly bactericidal with broad-spectrum activity. PF-5081090 serves as a regulator of lipid A biosynthesis in Gram-negative pathogens. | ||||||||||||||||||||
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PF-5081090 (Standard) | ≥98% | Cefalonium (dihydrate) (Standard) is the analytical standard of Cefalonium (dihydrate). This product is intended for research and analytical applications. Cefalonium dihydrate is a cephalosporin antibiotic. Cefalonium (dihydrate) is effective against Staphylococcus aureus. Cefalonium (dihydrate) has anti-inflammatory and antibacterial activities. | ||||||||||||||||||||
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References
- [1]. Tomaras AP, et al. LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens. mBio. 2014 Sep 30;5(5):e01551-14. [Content Brief]
- [2]. García-Quintanilla M, et al. Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii. Antimicrob Agents Chemother. 2016 Jul 22;60(8):5076-9. [Content Brief]
