131615-52-6
Chemical Structure
TISCH
- CAS No.: 131615-52-6
- Formula:C17H17ClINO
- Molecular Weight:413.68
IUPAC Name: (R)-8-chloro-5-(3-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol
InChIKey: DUTJKDUWCSYNLM-OAHLLOKOSA-N
SMILES: OC1=C(C=C2CCN(C[C@@H](C2=C1)C3=CC=CC(I)=C3)C)Cl
Biological Activity: TISCH is a potent and selective iodinated ligand with high affinity and selectivity for CNS D1 dopamine receptors. TISCH showed a Kd value of 0.205 nM in rat striatal tissue, indicating its effectiveness in biological activity. TISCH is able to easily cross the blood-brain barrier and show distribution in specific areas with D1 receptor density. TISCH is considered to be useful as a pharmacological tool for characterizing D1 dopamine receptors. When labeled with I-123, TISCH has the potential to be used as an in vivo imaging agent for CNS D1 dopamine receptors[1].
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TISCH | TISCH is a potent and selective iodinated ligand with high affinity and selectivity for CNS D1 dopamine receptors. TISCH showed a Kd value of 0.205 nM in rat striatal tissue, indicating its effectiveness in biological activity. TISCH is able to easily cross the blood-brain barrier and show distribution in specific areas with D1 receptor density. TISCH is considered to be useful as a pharmacological tool for characterizing D1 dopamine receptors. When labeled with I-123, TISCH has the potential to be used as an in vivo imaging agent for CNS D1 dopamine receptors. | |||||||||||||||||||||
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Keywords
