13392-28-4
Chemical Structure
Rimantadine
Synonym(s): 1-Rimantadine
- CAS No.: 13392-28-4
- Formula:C12H21N
- Molecular Weight:179.30
IUPAC Name: 1-((3r,5r,7r)-adamantan-1-yl)ethan-1-amine
InChIKey: UBCHPRBFMUDMNC-ULCLOTFOSA-N
SMILES: CC(C1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1)N
Biological Activity: Rimantadine (1-Rimantadine) is an orally active inhibitor for M2 protein, which blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity. Rimantadine significantly inhibits hepatitis A virus (HAV) replication at the post-entry stage in Huh7 cells. Rimantadine enhances autophagy. Rimantadine has a significant protective effect against H3N2 virus in mouse model[1][2].
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Rimantadine | 99.86% | Rimantadine (1-Rimantadine) is an orally active inhibitor for M2 protein, which blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity. Rimantadine significantly inhibits hepatitis A virus (HAV) replication at the post-entry stage in Huh7 cells. Rimantadine enhances autophagy. Rimantadine has a significant protective effect against H3N2 virus in mouse model. | ||||||||||||||||||||
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Rimantadine (Standard) | ≥98% | Rimantadine (Standard) is the analytical standard of Rimantadine. This product is intended for research and analytical applications. Rimantadine is an orally active inhibitor for M2 protein, that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity. | ||||||||||||||||||||
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- [1]. Sasaki-Tanaka R, et al., Amantadine and Rimantadine Inhibit Hepatitis A Virus Replication through the Induction of Autophagy. J Virol. 2022 Sep 28;96(18):e0064622. [Content Brief]
- [2]. Simeonova L, et al., Prophylactic and therapeutic combination effects of rimantadine and oseltamivir against influenza virus A (H3N2) infection in mice. Antiviral Res. 2012 Aug;95(2):172-81. [Content Brief]
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