1346603-87-9
1346603-87-9
Chemical Structure
2,5-Dimethylcelecoxib-d4
- CAS No.: 1346603-87-9
- Formula:C18H12D4F3N3O2S
- Molecular Weight:399.42
IUPAC Name: 4-(5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzene-2,3,5,6-d4-sulfonamide
InChIKey: NTFOSUUWGCDXEF-KDWZCNHSSA-N
SMILES: CC1=C(C=C(C=C1)C)C2=CC(C(F)(F)F)=NN2C3=C([2H])C([2H])=C(C([2H])=C3[2H])S(N)(=O)=O
Biological Activity: 4-(5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide-d4 is the deuterium labeled 4-(5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide[1].
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2,5-Dimethylcelecoxib-d4 | 4-(5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide-d4 is the deuterium labeled 4-(5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide. | |||||||||||||||||||||
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2,5-Dimethylcelecoxib | 99.57% | 2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the Wnt/β-catenin signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin. | ||||||||||||||||||||
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