1349719-98-7
Chemical Structure
(S)-JQ-35
Synonym(s): TEN-010
- CAS No.: 1349719-98-7
- Formula:C27H34ClN7OS
- Molecular Weight:540.12
IUPAC Name: (S)-2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(3-(4-methylpiperazin-1-yl)propyl)acetamide
InChIKey: PKQXLRYFPSZKDU-QFIPXVFZSA-N
SMILES: O=C(NCCCN1CCN(C)CC1)C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2
Biological Activity: (S)-JQ-35 (TEN-010) is an orally active, blood-brain barrier-permeable bromodomain inhibitor that selectively targets the bromodomain and extra-terminal domain (BET) protein family (BRD4, BRD3, BRD2 and BRDT). (S)-JQ-35 blocks the activation of Myc gene expression by BRD4, thereby inhibiting cancer cell proliferation and promoting cancer cell apoptosis. (S)-JQ-35 can be used in research related to NUT midline carcinoma and neuroblastoma[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-JQ-35 | 99.46% | (S)-JQ-35 (TEN-010) is an orally active, blood-brain barrier-permeable bromodomain inhibitor that selectively targets the bromodomain and extra-terminal domain (BET) protein family (BRD4, BRD3, BRD2 and BRDT). (S)-JQ-35 blocks the activation of Myc gene expression by BRD4, thereby inhibiting cancer cell proliferation and promoting cancer cell apoptosis. (S)-JQ-35 can be used in research related to NUT midline carcinoma and neuroblastoma. | ||||||||||||||||||||
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- [1]. Samples S, et al. Intrapericardial NUT Midline Carcinoma: Unusual Presentation of a Rare Tumor and Literature Review with Management Considerations. Pediatr Cardiol. 2016;37(1):208-211. [Content Brief]
- [2]. Firle KA, et al. Preclinical evaluation of BET-bromodomain inhibitor TEN-010 as monotherapy and combination therapy in MYC-driven neuroblastoma. Annals of Oncology. 2018 Mar 1;29:iii12-3.
Keywords
