1386811-71-7
1386811-71-7
Chemical Structure
GA32
- CAS. Nr.: 1386811-71-7
- Formula:C23H19N3O3S
- Molecular Weight:417.48
InChIKey: QWPDOAPBJDUXDW-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(NC(C2=CC=CC(S(=O)(N3C4=C(CCC3)C=CC=C4)=O)=C2)=O)C=C1
Biological Activity: GA32 (compound 58r) is potent androgen receptor (AR)/glucocorticoid receptor (GR) dual inhibitor with IC50 values of 0.13 μM and 0.83 μM for AR and GR, respectively. GA32 inhibits the proliferation of Enzalutamide (HY-70002) resistance castration-resistant prostate cancer both in vitro and in vivo[1].
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GA32 | 99.67% | GA32 (compound 58r) is potent androgen receptor (AR)/glucocorticoid receptor (GR) dual inhibitor with IC50 values of 0.13 μM and 0.83 μM for AR and GR, respectively. GA32 inhibits the proliferation of Enzalutamide (HY-70002) resistance castration-resistant prostate cancer both in vitro and in vivo. | ||||||||||||||||||||
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References
Keywords
