1388225-79-3
Chemical Structure
TSR-011-isomer
- CAS No.: 1388225-79-3
- Formula:C33H43F2N5O3
- Molecular Weight:595.72
IUPAC Name: 3,5-difluoro-N-((E)-6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)benzamide
InChIKey: GZYCQQBRSRIFII-JAQLMMITSA-N
SMILES: O=C(C1=CC(F)=CC(F)=C1)/N=C2NC3=CC=C(C=C3N\2[C@H]4CC[C@H](CC4)C(NC(C)C)=O)CN5CCC(CC5)C(O)(C)C
Biological Activity: TSR-011-isomer is an isomer of Belizatinib (HY-17603), a ALK inhibitor with an IC50 of 6 nM. TSR-011-isomer acts as a substrate for metabolic hydrolysis and NADPH-dependent metabolism. TSR-011-isomer undergoes enzymatic hydrolysis in mouse plasma and NADPH-dependent metabolism in mouse liver microsomes, thereby supporting clearance processes. TSR-011-isomer can be used in studies related to ALK-driven cancers[1].
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TSR-011-isomer | TSR-011-isomer is an isomer of Belizatinib (HY-17603), a ALK inhibitor with an IC50 of 6 nM. TSR-011-isomer acts as a substrate for metabolic hydrolysis and NADPH-dependent metabolism. TSR-011-isomer undergoes enzymatic hydrolysis in mouse plasma and NADPH-dependent metabolism in mouse liver microsomes, thereby supporting clearance processes. TSR-011-isomer can be used in studies related to ALK-driven cancers. | |||||||||||||||||||||
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