1391923-59-3
Chemical Structure
SPR519
- CAS No.: 1391923-59-3
- Formula:C19H21N7O3S
- Molecular Weight:427.48
IUPAC Name: 4-((4-(2-aminothiazol-5-yl)-6-morpholino-1,3,5-triazin-2-yl)oxy)-N,N-dimethylbenzamide
InChIKey: BQPZIYSVGQSCET-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(OC2=NC(=NC(=N2)N3CCOCC3)C=4SC(=NC4)N)C=C1)N(C)C
Biological Activity: SPR519 is a selective, orally active dual PI3Kα/mTOR kinase inhibitor, with an IC50 of 0.03 μM against PI3Kα and an IC50 of 0.01 μM against mTOR. SPR519 exhibits anticancer effects in ovarian cancer and colon cancer xenograft models. SPR519 can be used for the research of solid tumors (ovarian cancer, colon cancer)[1].
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SPR519 | SPR519 is a selective, orally active dual PI3Kα/mTOR kinase inhibitor, with an IC50 of 0.03 μM against PI3Kα and an IC50 of 0.01 μM against mTOR. SPR519 exhibits anticancer effects in ovarian cancer and colon cancer xenograft models. SPR519 can be used for the research of solid tumors (ovarian cancer, colon cancer). | |||||||||||||||||||||
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Keywords
