142754-28-7
Chemical Structure
Sp-8-Cl-cAMPS
- CAS No.: 142754-28-7
- Formula:C10H11ClN5O5PS
- Molecular Weight:379.72
IUPAC Name: (2S,4aR,6R,7R,7aS)-6-(6-amino-8-chloro-9H-purin-9-yl)-7-hydroxy-2-mercaptotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide
InChIKey: PJAHPRNGOHUYQD-FHIGPPGSSA-N
SMILES: S[P@@]1(O[C@H]2[C@@H](O)[C@H](N3C(Cl)=NC4=C3N=CN=C4N)O[C@@H]2CO1)=O
Biological Activity: Sp-8-Cl-cAMPS is an analog of cAMP (HY-B1511) and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC50 of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII, with Ka of 0.25 and 3.2 μM[1].
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Sp-8-Cl-cAMPS | Sp-8-Cl-cAMPS is an analog of cAMP (HY-B1511) and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC50 of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII, with Ka of 0.25 and 3.2 μM. | |||||||||||||||||||||
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Keywords
