1428417-60-0
Chemical Structure
Usenamine A
- CAS No.: 1428417-60-0
- Formula:C18H17NO6
- Molecular Weight:343.33
IUPAC Name: (R,E)-6-acetyl-2-(1-aminoethylidene)-7,9-dihydroxy-8,9b-dimethyldibenzo[b,d]furan-1,3(2H,9bH)-dione
InChIKey: SPBCRTZCVHEBTB-DBEXCURXSA-N
SMILES: C[C@@]12C3=C(O)C(C)=C(O)C(C(C)=O)=C3OC1=CC(/C(C2=O)=C(N)/C)=O
Biological Activity: Usenamine A is an orally active natural dibenzofuran compound with multiple biological activities such as anti-inflammatory and anticancer effects. Usenamine A inhibits the AKT/mTOR/STAT3/ID1 signaling axis and induces ubiquitin-proteasome degradation of ID1. Usenamine A targets the TNF-TNFR2 complex, inhibits RGS2, and interferes with Myosin-9/actin cytoskeleton remodeling. Usenamine A induces apoptosis, autophagy and ROS-mediated endoplasmic reticulum stress in cancer cells, inhibits cancer cell proliferation and invasion, and reduces the production of pro-inflammatory cytokines. Usenamine A alleviates arthritis-related symptoms. Usenamine A can be used in studies related to liver cancer, non-small cell lung cancer, rheumatoid arthritis and ankylosing spondylitis[1][2][3][4][5].
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Usenamine A | Usenamine A is an orally active natural dibenzofuran compound with multiple biological activities such as anti-inflammatory and anticancer effects. Usenamine A inhibits the AKT/mTOR/STAT3/ID1 signaling axis and induces ubiquitin-proteasome degradation of ID1. Usenamine A targets the TNF-TNFR2 complex, inhibits RGS2, and interferes with Myosin-9/actin cytoskeleton remodeling. Usenamine A induces apoptosis, autophagy and ROS-mediated endoplasmic reticulum stress in cancer cells, inhibits cancer cell proliferation and invasion, and reduces the production of pro-inflammatory cytokines. Usenamine A alleviates arthritis-related symptoms. Usenamine A can be used in studies related to liver cancer, non-small cell lung cancer, rheumatoid arthritis and ankylosing spondylitis. | |||||||||||||||||||||
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- [1]. Yang A, et al. Interfering with the AKT/mTOR/STAT3/ID1 signaling axis with usenamine A restrains the proliferative and invasive potential of human hepatocellular carcinoma cells. Chinese medicine. 2024 Jan 05;19(1):4. [Content Brief]
- [2]. Yang A, et al. Usenamine A induces apoptosis and autophagic cell death of human hepatoma cells via interference with the Myosin-9/actin-dependent cytoskeleton remodeling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jul 25;116:154895. [Content Brief]
- [3]. Lee YJ, et al. Usenamine A: a potential therapeutic agent for rheumatoid arthritis and ankylosing spondylitis through its anti-inflammatory activity. Frontiers in pharmacology. 2024;15:1456216. [Content Brief]
- [4]. Cheng L, et al. Usenamine A, an RGS2 inhibitor, exerts anti-NSCLC activity and enhances cytotoxicity of gemcitabine by inducing ER stress and Notch1-mediated autophagy. Bioorganic chemistry. 2025 Oct;165:109010. [Content Brief]
- [5]. Yu X L, et al. Usnic Acid Derivatives with Cytotoxic and Antifungal Activities from the Lichen Usnea longissima. Journal of Natural Products, 2016, 79(5): 1373-1380.
Keywords
