1438638-83-5
Chemical Structure
T-1101
Synonym(s): TAI-95
- CAS No.: 1438638-83-5
- Formula:C24H23N5O3S2
- Molecular Weight:493.60
IUPAC Name: N-(4-(4-((5-(2-methoxyethoxy)pyrazin-2-yl)thio)-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide
InChIKey: ICECVTFTHRPNOE-UHFFFAOYSA-N
SMILES: O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(SC4=NC=C(OCCOC)N=C4)C=C3C)=CS2
Biological Activity: T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models[1].
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T-1101 | T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models. | |||||||||||||||||||||
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T-1101-d7 | T-1101-d7 is the deuterium labeled T-1101. | |||||||||||||||||||||
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