T-1101
Based on 1 publication(s) in Google Scholar
T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1438638-83-5
- 分子式: C24H23N5O3S2
- 分子量:493.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
MedChemExpress(MCE)の使用を引用している文献 T-1101
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生物活性
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NEK2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COLO 205 | GI50 |
29.1 nM
Compound: 9j
|
Antiproliferative activity against human COLO 205 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human COLO 205 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| HeLa | IC50 |
21.1 nM
Compound: 9j
|
Antiproliferative activity against human HeLa cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human HeLa cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| Huh-7 | GI50 |
34.98 nM
Compound: 9j
|
Antiproliferative activity against human Huh-7 cells by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human Huh-7 cells by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| Huh-7 | GI50 |
59.9 nM
Compound: 9j
|
Anticancer activity against human Huh-7 cells after 24 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Anticancer activity against human Huh-7 cells after 24 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| K562 | IC50 |
18 nM
Compound: 9j
|
Antiproliferative activity against human K562 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human K562 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| MDA-MB-231 | IC50 |
14.8 nM
Compound: 9j
|
Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human MDA-MB-231 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| MDA-MB-468 | IC50 |
21.5 nM
Compound: 9j
|
Antiproliferative activity against human MDA-MB-468 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human MDA-MB-468 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| U2OS | GI50 |
83.2 nM
Compound: 9j
|
Antiproliferative activity against human U2OS cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human U2OS cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
| U-937 | GI50 |
12.4 nM
Compound: 9j
|
Antiproliferative activity against human U-937 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
Antiproliferative activity against human U-937 cells measured after 96 hrs by CellTiter 96 Aqueous One Solution Reagent based assay
|
[PMID: 32113126] |
化学情報
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CAS 番号 1438638-83-5
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分子量 493.60
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分子式 C24H23N5O3S2
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SMILES
O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(SC4=NC=C(OCCOC)N=C4)C=C3C)=CS2
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別名
TAI-95
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cancer Res Commun
Inhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden. [Abstract]2024 Apr 9;4(4):1024-1040. PMID: 38592451
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)