1451048-96-6
Chemical Structure
CDg13
- CAS 番号: 1451048-96-6
- Formula:C32H35Cl2NO4
- Molecular Weight:568.53
InChIKey: VHGXHVAEKXDRMO-UHFFFAOYSA-N
SMILES: CCCCCCN(C(C1=CC=C(C=C1)C2=C3C=C(C(C=C3OC4=C2C=C(C(O)=C4)Cl)=O)Cl)=O)CCCCCC
Biological Activity: CDg13 is a fluorescent probe that specifically detects living neural stem/progenitor cells. CDg13 localizes to the endoplasmic reticulum via its dihexyl moiety, with no interaction with endoplasmic reticulum biomolecules. CDg13 undergoes selective efflux by active ABCG2 transporters, with increased intracellular accumulation following ABCG2 inhibition or knockdown. CDg13 isolates and enriches self-renewable neural stem/progenitor cells from embryonic mouse brain tissue, stains neural stem/progenitor cells brightly, and sorts ABCG2low cell populations from heterogeneous populations[1]. (Ex/Em = 520/553 nm)
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CDg13 | CDg13 is a fluorescent probe that specifically detects living neural stem/progenitor cells. CDg13 localizes to the endoplasmic reticulum via its dihexyl moiety, with no interaction with endoplasmic reticulum biomolecules. CDg13 undergoes selective efflux by active ABCG2 transporters, with increased intracellular accumulation following ABCG2 inhibition or knockdown. CDg13 isolates and enriches self-renewable neural stem/progenitor cells from embryonic mouse brain tissue, stains neural stem/progenitor cells brightly, and sorts ABCG2low cell populations from heterogeneous populations. (Ex/Em = 520/553 nm) | |||||||||||||||||||||
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