1460286-21-8
1460286-21-8
Chemical Structure
MSC2504877
Synonym(s): M2912
- CAS No.: 1460286-21-8
- Formula:C17H18N2O2
- Molecular Weight:282.34
IUPAC Name: 3-(4-(2-hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one
InChIKey: MPXAEYSGFKRDQM-UHFFFAOYSA-N
SMILES: O=C1C2=CC=C(C)N2C=C(C3=CC=C(C(C)(O)C)C=C3)N1
Biological Activity: MSC2504877 (M2912) is a potent and orally active tankyrase inhibitor with IC50s of 0.0007, 0.0008, 0.54 µM for TNKS, TNKS2, PARP1, respectively. MSC2504877 increases the expression of AXIN2 and TNKS protein levels and decreases β-catenin levels. MSC2504877 shows anti-tumor activity[1].
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MSC2504877 | 99.25% | MSC2504877 (M2912) is a potent and orally active tankyrase inhibitor with IC50s of 0.0007, 0.0008, 0.54 µM for TNKS, TNKS2, PARP1, respectively. MSC2504877 increases the expression of AXIN2 and TNKS protein levels and decreases β-catenin levels. MSC2504877 shows anti-tumor activity. | ||||||||||||||||||||
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References
Keywords
