147025-53-4
Chemical Structure
Talsaclidine
Synonym(s): WAL 2014 FU free base
- CAS. Nr.: 147025-53-4
- Formula:C10H15NO
- Molecular Weight:165.24
IUPAC Name: (3R)-3-(prop-2-yn-1-yloxy)quinuclidine
InChIKey: XVFJONKUSLSKSW-JTQLQIEISA-N
SMILES: C#CCO[C@@H]1[C@@H]2CCN(CC2)C1
Biological Activity:
Talsaclidine (WAL 2014 FU) is an orally active, blood-brain barrier-permeable muscarinic M1 receptor agonist. Talsaclidine activates the sympathetic nervous system and promotes adrenal catecholamine release in vivo. Talsaclidine exhibits extensive tissue distribution, kidney-dominant excretion and brain penetration properties, and it can be used in studies related to cholinergic signaling, cognitive function and Alzheimer's disease[1][2][3][4].
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Talsaclidine | 98.75% | Talsaclidine (WAL 2014 FU) is an orally active, blood-brain barrier-permeable muscarinic M1 receptor agonist. Talsaclidine activates the sympathetic nervous system and promotes adrenal catecholamine release in vivo. Talsaclidine exhibits extensive tissue distribution, kidney-dominant excretion and brain penetration properties, and it can be used in studies related to cholinergic signaling, cognitive function and Alzheimer's disease. |
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References
- [1]. Leusch A, et al. Pharmacokinetics of the M1-agonist talsaclidine in mouse, rat, rabbit and monkey, and extrapolation to man. Xenobiotica; the fate of foreign compounds in biological systems. 2000 Aug;30(8):797-813.
- [2]. Walland A, et al. In vivo consequences of M1-receptor activation by talsaclidine. Life sciences. 1997;60(13-14):977-84. [Content Brief]
- [3]. Terry AV Jr, et al. Memory-related task performance by aged rhesus monkeys administered the muscarinic M1-preferring agonist, talsaclidine. Psychopharmacology. 2002;162:292-300.
- [4]. Walland A, et al. Compensation of muscarinic bronchial effects of talsaclidine by concomitant sympathetic activation in guinea pigs. European journal of pharmacology. 1997 Jul 09;330(2-3):213-9. [Content Brief]
