150013-70-0
Chemical Structure
PD-143188
Synonym(s): CI 1007
- CAS No.: 150013-70-0
- Formula:C24H27N
- Molecular Weight:329.48
IUPAC Name: (R)-4-phenyl-1-((2,3,4,5-tetrahydro-[1,1'-biphenyl]-3-yl)methyl)-1,2,3,6-tetrahydropyridine
InChIKey: XBGWTWPYCTZIIE-HXUWFJFHSA-N
SMILES: C1(C2=CC=CC=C2)=CCN(C[C@H]3CC(C4=CC=CC=C4)=CCC3)CC1
Biological Activity: PD-143188 (CI 1007) is a selective agonist targeting dopamine (DA) receptors, with Ki values of 25.5 nM and 16.6 nM for human D2 and D3 receptors, respectively and lower affinity for D4.2 receptors (Ki=90.9 nM). PD-143188 inhibits DA release, synthesis and metabolism, while reducing cellular cyclic AMP levels, exerting antipsychotic activity. PD-143188 is promising for research of psychopharmacology[1].
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PD-143188 | PD-143188 (CI 1007) is a selective agonist targeting dopamine (DA) receptors, with Ki values of 25.5 nM and 16.6 nM for human D2 and D3 receptors, respectively and lower affinity for D4.2 receptors (Ki=90.9 nM). PD-143188 inhibits DA release, synthesis and metabolism, while reducing cellular cyclic AMP levels, exerting antipsychotic activity. PD-143188 is promising for research of psychopharmacology. | |||||||||||||||||||||
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Keywords
