1518800-36-6
Chemical Structure
Afabicin diolamine
Synonym(s): Debio 1450 diolamine; AFN-1720 diolamine
- CAS No.: 1518800-36-6
- Formula:C27H38N5O9P
- Molecular Weight:607.59
IUPAC Name: 2-aminoethan-1-ol (E)-(6-(3-(methyl((3-methylbenzofuran-2-yl)methyl)amino)-3-oxoprop-1-en-1-yl)-2-oxo-3,4-dihydro-1,8-naphthyridin-1(2H)-yl)methyl phosphate
InChIKey: RLXLAXQJCXOHNX-OJYIHNBOSA-N
SMILES: OCCN.O=P(O)(O)OCN1C2=NC=C(/C=C/C(N(C)CC3=C(C)C4=CC=CC=C4O3)=O)C=C2CCC1=O.OCCN
Biological Activity: Afabicin diolamine (Debio 1450 diolamine) is the proagent of Debio1452 (HY-16911), specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci[1].
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Afabicin diolamine | Afabicin diolamine (Debio 1450 diolamine) is the proagent of Debio1452 (HY-16911), specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. | |||||||||||||||||||||
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Keywords
