1539266-32-4
Chemical Structure
25CN-NBOH hydrochloride
- CAS No.: 1539266-32-4
- Formula:C18H21ClN2O3
- Molecular Weight:348.82
IUPAC Name: 4-(2-((2-hydroxybenzyl)amino)ethyl)-2,5-dimethoxybenzonitrile hydrochloride
InChIKey: JQVAEIIIMVMJBO-UHFFFAOYSA-N
SMILES: N#CC1=C(OC)C=C(CCNCC2=C(O)C=CC=C2)C(OC)=C1.Cl
Biological Activity: 25CN-NBOH hydrochloride exhibits agonist activity at the 5-HT2a receptor, shows 90- to 100-fold selectivity over the 5-HT2c receptor, and possesses blood-brain barrier permeability[1][2][3]. 25CN-NBOH hydrochloride acts as an interoceptive agent with partial agonist-like properties[1][2][3]. 25CN-NBOH hydrochloride serves as a pharmacological tool for 5-HT2A receptor research, and its tritiated form functions as a selective agonist radioligand[1]. 25CN-NBOH hydrochloride can be used to investigate diseases characterized by cognitive rigidity, schizophrenia, obsessive-compulsive disorder, depression, pain, inflammation, migraine, and cluster headache[1][3].
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25CN-NBOH hydrochloride | 25CN-NBOH hydrochloride exhibits agonist activity at the 5-HT2a receptor, shows 90- to 100-fold selectivity over the 5-HT2c receptor, and possesses blood-brain barrier permeability. 25CN-NBOH hydrochloride acts as an interoceptive agent with partial agonist-like properties. 25CN-NBOH hydrochloride serves as a pharmacological tool for 5-HT2A receptor research, and its tritiated form functions as a selective agonist radioligand. 25CN-NBOH hydrochloride can be used to investigate diseases characterized by cognitive rigidity, schizophrenia, obsessive-compulsive disorder, depression, pain, inflammation, migraine, and cluster headache. | |||||||||||||||||||||
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- [1]. Jensen AA, et al. The selective 5-HT2A receptor agonist 25CN-NBOH: Structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH. Biochem Pharmacol. 2020 Jul;177:113979.
- [2]. Fantegrossi WE, et al. Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT₂A receptors, in mice. Psychopharmacology (Berl). 2015 Mar;232(6):1039-47. [Content Brief]
- [3]. Hansen M, et al. Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS Chem Neurosci. 2014 Mar 19;5(3):243-9. [Content Brief]
Keywords
