1569309-92-7
Chemical Structure
DBIBB
- CAS No.: 1569309-92-7
- Formula:C23H20N2O6S
- Molecular Weight:452.48
IUPAC Name: 2-(N-(4-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)butyl)sulfamoyl)benzoic acid
InChIKey: POLJNARIJSROOS-UHFFFAOYSA-N
SMILES: O=C(N1CCCCNS(C2=C(C=CC=C2)C(O)=O)(=O)=O)C3=C4C(C=CC=C4C1=O)=CC=C3
Biological Activity: DBIBB is a specific nonlipid agonist of the type 2 G protein coupled receptor for lysophosphatidic acid (LPA2). DBIBB mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation, and reduces apoptosis. DBIBB represents a agent candidate capable of mitigating acute radiation syndrome caused by high-dose γ-radiation to the hematopoietic and gastrointestinal system[1].
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DBIBB | 98.07% | DBIBB is a specific nonlipid agonist of the type 2 G protein coupled receptor for lysophosphatidic acid (LPA2). DBIBB mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation, and reduces apoptosis. DBIBB represents a agent candidate capable of mitigating acute radiation syndrome caused by high-dose γ-radiation to the hematopoietic and gastrointestinal system. | ||||||||||||||||||||
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