2. Apoptosis
  3. Apoptosis
  4. DBIBB

DBIBB is a specific nonlipid agonist of the type 2 G protein coupled receptor for lysophosphatidic acid (LPA2). DBIBB mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation, and reduces apoptosis. DBIBB represents a agent candidate capable of mitigating acute radiation syndrome caused by high-dose γ-radiation to the hematopoietic and gastrointestinal system.

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DBIBB Chemical Structure

DBIBB Chemical Structure

CAS No. : 1569309-92-7

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 193 In-stock
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10 mg USD 280 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

DBIBB is a specific nonlipid agonist of the type 2 G protein coupled receptor for lysophosphatidic acid (LPA2). DBIBB mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation, and reduces apoptosis. DBIBB represents a agent candidate capable of mitigating acute radiation syndrome caused by high-dose γ-radiation to the hematopoietic and gastrointestinal system[1].

Molecular Weight

452.48

Formula

C23H20N2O6S
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(N1CCCCNS(C2=C(C=CC=C2)C(O)=O)(=O)=O)C3=C4C(C=CC=C4C1=O)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (221.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2100 mL 11.0502 mL 22.1004 mL
5 mM 0.4420 mL 2.2100 mL 4.4201 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2100 mL 11.0502 mL 22.1004 mL 55.2511 mL
5 mM 0.4420 mL 2.2100 mL 4.4201 mL 11.0502 mL
10 mM 0.2210 mL 1.1050 mL 2.2100 mL 5.5251 mL
15 mM 0.1473 mL 0.7367 mL 1.4734 mL 3.6834 mL
20 mM 0.1105 mL 0.5525 mL 1.1050 mL 2.7626 mL
25 mM 0.0884 mL 0.4420 mL 0.8840 mL 2.2100 mL
30 mM 0.0737 mL 0.3683 mL 0.7367 mL 1.8417 mL
40 mM 0.0553 mL 0.2763 mL 0.5525 mL 1.3813 mL
50 mM 0.0442 mL 0.2210 mL 0.4420 mL 1.1050 mL
60 mM 0.0368 mL 0.1842 mL 0.3683 mL 0.9209 mL
80 mM 0.0276 mL 0.1381 mL 0.2763 mL 0.6906 mL
100 mM 0.0221 mL 0.1105 mL 0.2210 mL 0.5525 mL
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DBIBB Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBIBB1569309-92-7ApoptosisnonlipidLPA2gastrointestinalradiation syndromeproliferationenterocyteapoptosishematopoieticInhibitorinhibitorinhibit

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