15982-84-0
15982-84-0
Chemical Structure
(E/Z)-BCI
Synonym(s): NSC 150117
- CAS No.: 15982-84-0
- Formula:C22H23NO
- Molecular Weight:317.42
IUPAC Name: (Z)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one
InChIKey: XJDKPLZUXCIMIS-HKWRFOASSA-N
SMILES: O=C1/C(C(NC2CCCCC2)C3=C1C=CC=C3)=C\C4=CC=CC=C4
Biological Activity: (E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway[1].
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(E/Z)-BCI | 99.38% | (E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway. | ||||||||||||||||||||
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References
Keywords
