1627576-64-0
1627576-64-0
Chemical Structure
JJC8-089
- CAS No.: 1627576-64-0
- Formula:C22H28F2N2OS
- Molecular Weight:406.53
InChIKey: MQDDJWTVOBHYHX-UHFFFAOYSA-N
SMILES: CC(CN1CCN(CC1)CCSC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)O
Biological Activity: JJC8-089 is a dopamine transporter (DAT) inhibitor that may improve motivational dysfunction and increase effortful behavior in goal-directed activities. JJC8-089 significantly reversed the low-effort effects induced by the VMAT-2 inhibitor Tetrabenazine (HY-B0590) in rats and increased the choice of high-effort fixed-ratio 5-bar presses versus food intake. [1][2].
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JJC8-089 | JJC8-089 is a dopamine transporter (DAT) inhibitor that may improve motivational dysfunction and increase effortful behavior in goal-directed activities. JJC8-089 significantly reversed the low-effort effects induced by the VMAT-2 inhibitor Tetrabenazine (HY-B0590) in rats and increased the choice of high-effort fixed-ratio 5-bar presses versus food intake. . | |||||||||||||||||||||
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References
- [1]. Ecevitoglu A, et al. Potential therapeutics for effort-related motivational dysfunction: assessing novel atypical dopamine transport inhibitors. Neuropsychopharmacology. 2024 Mar 1. [Content Brief]
- [2]. Tunstall BJ, et al. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 2018 Mar 15;131:96-103. [Content Brief]
Keywords
