1644664-11-8
1644664-11-8
Chemical Structure
AMG-34
- CAS 番号: 1644664-11-8
- Formula:C33H27FN6O2
- Molecular Weight:558.60
IUPAC Name: 4-(2-amino-3-(5-fluoro-2-(methylamino)quinazolin-6-yl)-4-methylbenzoyl)-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one
InChIKey: HBWCGZWIVPNFPT-UHFFFAOYSA-N
SMILES: CN(N(C1=CC=CC=C1)C2=O)C(C3=CC=CC=C3)=C2C(C4=CC=C(C)C(C5=C(F)C6=CN=C(NC)N=C6C=C5)=C4N)=O
Biological Activity: AMG-34 is a GCN2-targeting agent with IC50 values of 0.395 μM, 0.010 μM, 1.07 μM and ＞ 10 μM for GCN2, PERK, HRland PKR, respectively[1].
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AMG-34 | AMG-34 is a GCN2-targeting agent with IC50 values of 0.395 μM, 0.010 μM, 1.07 μM and ＞ 10 μM for GCN2, PERK, HRland PKR, respectively. | |||||||||||||||||||||
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References
Keywords
