AMG-34
AMG-34 is a GCN2-targeting agent with IC50 values of 0.395 μM, 0.010 μM, 1.07 μM and ＞ 10 μM for GCN2, PERK, HRland PKR, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1644664-11-8
- Formula: C33H27FN6O2
- Molecular Weight:558.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
AMG-34 (0-10 μM, 72 h) exhibits a U-shaped viability response in MOLM-16 cells, causing the most significant decrease in cell viability at intermediate concentrations (around 0.1 μM), while showing reduced inhibitory effects at both lower and higher concentrations[1].
AMG-34 (0.01-0.37 μM, 8 h) increases the expression of ATF4 in MOLM-16 cells[1].
AMG-34 (1.1-10 μM, 8 h) inhibits the expression of p-GCN2 while shows no effect on the expression of GCN2 in MOLM-16 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1644664-11-8
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Molecular Weight 558.60
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Formula C33H27FN6O2
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SMILES
CN(N(C1=CC=CC=C1)C2=O)C(C3=CC=CC=C3)=C2C(C4=CC=C(C)C(C5=C(F)C6=CN=C(NC)N=C6C=C5)=C4N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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