167820-10-2
Chemical Structure
CHEMBL333994
Synonym(s): FK-480
- CAS No.: 167820-10-2
- Formula:C26H19FN4O2
- Molecular Weight:438.45
IUPAC Name: (R)-N-(1-(2-fluorophenyl)-4-oxo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-3-yl)-1H-indole-2-carboxamide
InChIKey: WKJDXKWFGJWGAS-DEOSSOPVSA-N
SMILES: O=C(C(N1)=CC2=C1C=CC=C2)N[C@H]3C(N4C5=C(CC4)C=CC=C5C(C6=CC=CC=C6F)=N3)=O
Biological Activity: CHEMBL333994 (FK-480) is a potent and orally active Cholecystokinin A receptor (CCK-A receptor) antagonist, with an IC50 of 0.67 nM. CHEMBL333994 selectively antagonizes peripheral CCK receptors. CHEMBL333994 increases CCK mRNA level. CHEMBL333994 can be used for research of chronic pancreatitis[1][2][3].
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CHEMBL333994 | CHEMBL333994 (FK-480) is a potent and orally active Cholecystokinin A receptor (CCK-A receptor) antagonist, with an IC50 of 0.67 nM. CHEMBL333994 selectively antagonizes peripheral CCK receptors. CHEMBL333994 increases CCK mRNA level. CHEMBL333994 can be used for research of chronic pancreatitis. | |||||||||||||||||||||
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- [1]. Satoh Y, et al. Studies on a novel, potent and orally effective cholecystokinin A antagonist, FK-480. Synthesis and structure-activity relationships of FK-480 and related compounds. Chem Pharm Bull (Tokyo). 1994 Oct;42(10):2071-83. [Content Brief]
- [2]. Funakoshi A,et al. Effect of a new cholecystokinin antagonist (FK 480) on gene expression of cholecystokinin and secretin in rat intestine. J Gastroenterol. 1994 Jun;29(3):385-7. [Content Brief]
- [3]. Moriyoshi Y, et al. Duration of anti-cholecystokinin (CCK) action on the rat exocrine pancreas of new CCK receptor antagonist FK480 administered orally. J Gastroenterol. 1996 Apr;31(2):249-53 [Content Brief]
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